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Radiation-enhancing effect of sodium glycididazole in patients suffering from non-small cell lung cancer with multiple brain metastases: A randomized, placebo-controlled study.
Zeng, Y C; Wu, R; Xing, R; Chi, F; Wang, S L; Chen, X D; Xuan, Y; Wu, L N; Duan, Q Y; Tang, M Y; Niu, N; Sun, Y N; Fan, G L; Wang, H M.
Afiliación
  • Zeng YC; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Wu R; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China. Electronic address: 511695796@qq.com.
  • Xing R; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Chi F; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Wang SL; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Chen XD; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Xuan Y; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Wu LN; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Duan QY; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Tang MY; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Niu N; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Sun YN; Department of Medical Oncology, Cancer Center, Shengjing Hospital of China Medical University, 39, Huaxiang Road, Shenyang 110022, China.
  • Fan GL; Department of Otorhinolaryngology, Harbin First Hospital, 151, Diduan Street, Harbin 150010, China.
  • Wang HM; Department of Radiation Oncology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.
Cancer Radiother ; 20(3): 187-92, 2016 May.
Article en En | MEDLINE | ID: mdl-27052296
PURPOSE: Median survival of patients with brain metastases from non-small cell lung cancer is poor. This study was to investigate the radiation-enhancing effect of sodium glycididazole combined with whole-brain radiotherapy of multiple brain metastases from non-small cell lung cancer. PATIENTS AND METHODS: Sixty-four patients with multiple brain metastases from non-small cell lung cancer were included: the study group (n=32) received whole-brain radiotherapy combined with sodium glycididazole at a dose of 700mg/m(2) intravenous infusion 30minutes before radiotherapy, three times a week; the control group (n=32) only received whole-brain radiotherapy. The primary end point was central nervous system (CNS) progression-free survival and overall survival. The treatment-related toxicity was also recorded. RESULTS: The CNS disease control rate was better (90.6% vs 65.6%, P=0.016) in the study group than in the control group at 3 month of follow-up. The median CNS progression-free survival time was longer in the study group than in the control group (7.0 months vs 4.0 months, P=0.038). There was no significant difference of the median overall survival time between the study group and the control group (11.0 months vs 9.0 months, P=0.418). On the other hand, the treatment-related toxicity showed no statistically significant difference between these two groups (P>0.05). CONCLUSIONS: The study indicated that sodium glycididazole was an effective, promising radiation-enhancing agent that improved CNS disease control rate, extended the median CNS progression-free survival time and was well tolerated in patients suffering from non-small cell lung cancer with multiple brain metastases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 Problema de salud: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Asunto principal: Fármacos Sensibilizantes a Radiaciones / Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Imidazoles / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Radiother Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2016 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 Problema de salud: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Asunto principal: Fármacos Sensibilizantes a Radiaciones / Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Imidazoles / Neoplasias Pulmonares Tipo de estudio: Clinical_trials Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Radiother Asunto de la revista: NEOPLASIAS / RADIOTERAPIA Año: 2016 Tipo del documento: Article País de afiliación: China
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