Orthostatic intolerance and fatigue in the hypermobility type of Ehlers-Danlos Syndrome.
Rheumatology (Oxford)
; 55(8): 1412-20, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-27094596
ABSTRACT
OBJECTIVE:
To investigate whether orthostatic intolerance (OI) is a significant predictor for fatigue in Ehlers-Danlos Syndrome, hypermobility type (EDS-HT).METHODS:
Eighty patients with EDS-HT and 52 controls participated in the first part of the study, which consisted of questionnaires. Fatigue was evaluated using the Checklist Individual Strength (CIS). As possible fatigue determinants OI [Autonomic Symptom Profile (ASP)], habitual physical activity (Baecke), affective distress [Hospital Anxiety and Depression Scale (HADS)], pain (SF36), medication use and generalized hypermobility (5-point score of Grahame and Hakim regarding generalized joint hypermobility) were studied. Next, a 20 min head-up tilt (70°) was performed in a subsample of 39 patients and 35 controls, while beat-to-beat heart rate and blood pressure were monitored (Holter, Finometer Pro). Before and after tilt, fatigue severity was assessed using a numeric rating scale.RESULTS:
Patients scored significantly higher on the CIS [total score EDS 98.2 (18.63) vs controls 45.8 (16.62), P < 0.001] and on the OI domain of the ASP [EDS 22.78 (7.16) vs controls 6.5 (7.78)]. OI was prevalent in EDS-HT (EDS 74.4%, controls 34.3%, P = 0.001), and frequently expressed as postural orthostatic tachycardia (41.0% of the EDS group). Patients responded to tilt with a higher heart rate and lower total peripheral resistance (p < 0.001; p = 0.032). This altered response correlated with fatigue in daily life (CIS). In the EDS-HT group, tilt provoked significantly more fatigue [numeric rating scale increase EDS +3.1 (1.90), controls +0.5 (1.24), P < 0.001]. Furthermore, the factors OI, pain, affective distress, decreased physical activity and sedative use explained 47.7% of the variance in fatigue severity.CONCLUSION:
OI is an important determinant of fatigue in EDS-HT.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Ehlers-Danlos
/
Intolerancia Ortostática
/
Fatiga
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Rheumatology (Oxford)
Asunto de la revista:
REUMATOLOGIA
Año:
2016
Tipo del documento:
Article