Neoalbaconol inhibits cell growth of human cholangiocarcinoma cells by up-regulating PTEN.
Am J Transl Res
; 8(2): 496-505, 2016.
Article
en En
| MEDLINE
| ID: mdl-27158342
ABSTRACT
The recently isolated small-molecule neoalbaconol (NA) from Albatrellus confluens has been suggested to possess the ability to inhibit cell growth of many cancer cells. In this study, we investigated the role of NA in the regulation of cell apoptosis in human cholangiocarcinoma cell lines both in vitro and in vivo. Our results indicate that NA could induce cancer cell death via the AKT pathway by targeting phosphorate and tension homolog detected on chromosome 10 (PTEN) and supported the feasibility of NA being a novel chemotherapeutic treatment for human cholangiocarcinoma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Am J Transl Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
China