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One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid.
Deng, Hongzhang; Zhao, Xuefei; He, Dongxuan; Guo, Weisheng; Yang, Keni; Dong, Anjie; Liang, Xing-Jie.
Afiliación
  • Deng H; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. ajdong@tju.edu.cn and CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiy
  • Zhao X; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. ajdong@tju.edu.cn.
  • He D; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. ajdong@tju.edu.cn and CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiy
  • Guo W; CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.
  • Yang K; CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.
  • Dong A; Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. ajdong@tju.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
  • Liang XJ; CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China.
Chem Commun (Camb) ; 52(46): 7406-8, 2016 May 31.
Article en En | MEDLINE | ID: mdl-27196702
A new type of membrane fusogenic lipid was prepared to deliver DNA or siRNA into the cytoplasm directly in a fusion-dependent manner in order to bypass the cellular endocytosis to avoid the inefficient escape from the endosome and low transfection efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Técnicas de Transferencia de Gen / Fusión de Membrana / Lípidos de la Membrana Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Técnicas de Transferencia de Gen / Fusión de Membrana / Lípidos de la Membrana Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article