Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice.
Nanomedicine (Lond)
; 11(11): 1393-406, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-27221077
ABSTRACT
AIM:
To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis. MATERIALS &METHODS:
Lipo-SP was prepared by the film-ultrasonic method, and physicochemical and pharmacokinetic characterized for oral administration (10 and 20 mg/kg for SP-loaded liposome; 20 mg/kg for free SP) in a mouse model bleomycin-induced ALI.RESULTS:
Lipo-SP enhanced bioavailability of SP with significant amelioration in lung pathology. Mechanistically, SP-mediated mineralocorticoid receptor antagonism contributes to inflammatory monocyte/macrophage modulation via an inhibitory effect on Ly6C(hi) monocytosis-directed M2 polarization of alveolar macrophages. Moreover, Lipo-SP at lower dose (10 mg/kg) exhibited more improvement in body weight gain.CONCLUSION:
Our data highlight Lipo-SP as a promising approach with therapeutic/preventive potential for ALI and fibrosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espironolactona
/
Monocitos
/
Macrófagos Alveolares
/
Antagonistas de Receptores de Mineralocorticoides
/
Lesión Pulmonar Aguda
/
Antiinflamatorios
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2016
Tipo del documento:
Article
País de afiliación:
China