Tumour control and Quality of Life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy.
Radiother Oncol
; 120(1): 163-8, 2016 07.
Article
en En
| MEDLINE
| ID: mdl-27247053
ABSTRACT
PURPOSE:
To assess clinical outcomes in children with rhabdomyosarcoma (RMS) treated with pencil beam scanning (PBS) proton therapy (PT). METHODS AND MATERIALS Eighty-three RMS (embryonal, n=74; 89%) patients treated between January 2000 and December 2014 were included. The median age was 4.5years (range, 0.8-15.5). All patients received systemic chemotherapy according to prospective protocols. Patients had low-, intermediate-, and high-risk disease in 24%, 63%, and 13% of cases, respectively. The median total dose delivered was 54Gy(RBE) (range, 41.4-64.8).RESULTS:
After a median follow-up time of 55.5 months (range, 0.9-126.3), local failure occurred in 16 patients. The 5-year local-control survival rate was 78.5% [95% confidence interval (CI), 69.5-88.5%]. Significant predictors for local failure were group/stage, tumour location, and size. Fourteen patients (16%) died, all from tumour progression. The 5-year overall survival was 80.6% (95%CI, 71.8-90.0%). The 5-year incidence of grade 3 non-ocular late toxicity was 3.6% (95%CI, 1-12%). No grade 4-5 late toxicities were observed. One radiation-induced malignancy was observed (1.2%). The Quality of Life (QoL) scores increased significantly after PT compared to baseline values.CONCLUSIONS:
PBS PT led to excellent outcome in children with RMS. Late non-ocular toxicity was minimal and QoL good.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
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2_ODS3
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7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de salud:
1_doencas_nao_transmissiveis
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2_muertes_prematuras_enfermedades_notrasmisibles
/
2_muertes_prevenibles
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7_non_communicable_diseases
Asunto principal:
Calidad de Vida
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Rabdomiosarcoma
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Terapia de Protones
Tipo de estudio:
Guideline
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Prognostic_studies
Aspecto:
Patient_preference
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Radiother Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Suiza