Membrane progesterone receptors in reproduction and cancer.
Mol Cell Endocrinol
; 434: 166-75, 2016 10 15.
Article
en En
| MEDLINE
| ID: mdl-27368976
ABSTRACT
Progesterone is a sexual steroid hormone that has a critical role in reproductive processes in males and females of several species, including humans. Furthermore, progesterone has been associated with pathological diseases such as breast, gynecological and brain cancer, regulating cell proliferation, apoptosis, and metastasis. In the past, progesterone actions were thought to be only mediated by its intracellular receptor (PR). However, recent evidence has demonstrated that membrane progesterone receptors (mPRs) mediate most of the non-classical progesterone actions. The role of the different mPRs subtypes in progesterone effects in reproduction and cancer is an emerging and exciting research area. Here we review studies to date regarding mPRs role in reproduction and cancer and discuss their functions and clinical relevance, suggesting mPRs as putative pharmacological targets and disease markers in cancer and diseases associated with reproduction.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reproducción
/
Receptores de Progesterona
/
Membrana Celular
/
Neoplasias
Límite:
Animals
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Female
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Humans
/
Male
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
2016
Tipo del documento:
Article
País de afiliación:
México