A novel compound 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide downregulates TSLP through blocking of caspase-1/NF-&#954;B pathways.

Moon, Phil-Dong; Han, Na-Ra; Ryu, Ka-Jung; Kang, Sang-Woo; Go, Ji-Hyun; Jang, Jae-Bum; Choi, Youngjin; Kim, Hyung-Min; Jeong, Hyun-Ja

A novel compound 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide downregulates TSLP through blocking of caspase-1/NF-κB pathways.

Moon, Phil-Dong; Han, Na-Ra; Ryu, Ka-Jung; Kang, Sang-Woo; Go, Ji-Hyun; Jang, Jae-Bum; Choi, Youngjin; Kim, Hyung-Min; Jeong, Hyun-Ja.

Afiliación

Moon PD; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
Han NR; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
Ryu KJ; Department of Pharmacology, Graduate School, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Kang SW; Department of Pharmacology, Graduate School, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Go JH; Department of Pharmacology, Graduate School, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Jang JB; Department of Pharmaceutical engineering and Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam 336-795, Republic of Korea.
Choi Y; Department of Food Technology and Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam 336-795 Republic of Korea.
Kim HM; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea. Electronic address: hmkim@khu.ac.kr.
Jeong HJ; Department of Food Technology and Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam 336-795 Republic of Korea. Electronic address: hjjeong@hoseo.edu.

Int Immunopharmacol ; 38: 420-5, 2016 Sep.

Article en En | MEDLINE | ID: mdl-27376852

Asunto(s)

Acetamidas/uso terapéutico; Antialérgicos/uso terapéutico; Citocinas/metabolismo; Dermatitis Atópica/tratamiento farmacológico; Hidrazonas/farmacología; Mastocitos/efectos de los fármacos; Acetamidas/síntesis química; Acetamidas/farmacología; Animales; Antialérgicos/síntesis química; Caspasa 1/metabolismo; Línea Celular; Biología Computacional/métodos; Citocinas/genética; Modelos Animales de Enfermedad; Descubrimiento de Drogas; Humanos; Hidrazonas/síntesis química; Mastocitos/fisiología; Ratones; Ratones Endogámicos; FN-kappa B/metabolismo; Transducción de Señal/efectos de los fármacos; Bibliotecas de Moléculas Pequeñas; Acetato de Tetradecanoilforbol; Linfopoyetina del Estroma Tímico

Palabras clave

2-(4-{2-[(Phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide; Caspase-1; Nuclear factor-κB; Thymic stromal lyemphopoietin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Antialérgicos / Dermatitis Atópica / Hidrazonas / Acetamidas / Mastocitos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article

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