Biomarcadores de Tumor/metabolismo; Neoplasias Encefálicas/diagnóstico por imagen; Espectroscopía de Resonancia Magnética con Carbono-13/métodos; Glioma/diagnóstico por imagen; Isocitrato Deshidrogenasa/metabolismo; Ácido Láctico/metabolismo; Ácido Pirúvico/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Glioma/genética; Glioma/metabolismo; Humanos; Células Tumorales Cultivadas

2-HG, 2-hydroxyglutarate; AIF, arterial input function; AUC, area under the curve; DNP, dynamic nuclear polarization; DNP-MR, dynamic nuclear polarization magnetic resonance; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; FA, flip angle; FGF, fibroblast growth factor; FLAIR, fluid attenuated inversion recovery; FOV, field of view; GBM, glioblastoma; Glioma; Hyperpolarized 13C Magnetic Resonance Spectroscopy (MRS); IDH1, isocitrate dehydrogenase 1; Isocitrate dehydrogenase 1 (IDH1) mutation; LDHA, lactate dehydrogenase A; MCT1, monocarboxylate transporter 1; MCT4, monocarboxylate transporter 4; MR, magnetic resonance; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopic imaging; MRS, magnetic resonance spectroscopy; Metabolic reprogramming; NA, number of averages; NT, number of transients; PBS, phosphate-buffer saline; PDGF, platelet-derived growth factor; PET, positron emission tomography; PI3K, phosphoinositide 3-kinase; PTEN, phosphatase and tensin homolog; RB1, retinoblastoma protein 1; SLC16A1, solute carrier family 16 member 1; SLC16A3, solute carrier family 16 member 3; SNR, signal-to-noise ratio; SW, spectral width; TCGA, The Cancer Genome Atlas; TE, echo time; TMZ, temozolomide; TP53, tumor protein p53; TR, repetition time; Tacq, acquisition time; VOI, voxel of interest; mTOR, mammalian target of rapamycin; α-KG, α-ketoglutarate