EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS).
J Zoo Wildl Med
; 47(2): 397-404, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27468009
ABSTRACT
ε-Aminocaproic acid (EACA) is a lysine analogue antifibrinolytic drug used to treat bleeding disorders in humans and domestic animals. Use in zoological medicine is rare and dose recommendations are anecdotal, but EACA may be a valuable therapeutic option for bleeding disorders in exotic species, including Asian elephants ( Elephas maximus ). This study used an in vitro model of hyperfibrinolysis and a thromboelastograph-based assay to estimate the therapeutic plasma concentration of EACA in Asian elephants (61.5 µg/ml, 95% CI = 34.6-88.5 µg/ml). Substantial but incomplete inhibition of lysis was seen at relatively low concentrations of EACA (40 µg/ml). Asian elephants appear sensitive to EACA-mediated inhibition of hyperfibrinolysis. Doses published for domestic animals, targeting higher plasma concentrations, may be inappropriate in this species.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Elefantes
/
Fibrinólisis
/
Ácido Aminocaproico
/
Antifibrinolíticos
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Zoo Wildl Med
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2016
Tipo del documento:
Article