Para-Dichlorobenzene Exposure Is Associated with Thyroid Dysfunction in US Adolescents.
J Pediatr
; 177: 238-243, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27476635
ABSTRACT
OBJECTIVE:
To examine the association between exposure to para-dichlorobenzene, measured as urinary concentrations of 2,5-dichlorophenol (2,5-DCP), and thyroid function in US adolescents. STUDYDESIGN:
A nationally representative subsample of 618 adolescents aged 12-19 years in the 2007-2008 and 2011-2012 National Health and Nutrition Examination Survey was analyzed for the association of urinary 2,5-DCP with serum thyroid function measures using multivariate logistic and general linear regression models.RESULTS:
After adjusting for potential confounders, we found a significantly positive association between urinary concentrations of 2,5-DCP and serum levels of thyroid-stimulating hormone and thyroglobulin in adolescents. Furthermore, urinary 2,5-DCP was associated with an increased prevalence of hypothyroidism in the study population.CONCLUSIONS:
This study demonstrates a potential relationship between para-dichlorobenzene exposure, measured as urinary 2,5-DCP, and thyroid dysfunction in adolescents; however, further studies are needed to confirm our findings and to elucidate mechanisms of action.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de la Tiroides
/
Glándula Tiroides
/
Clorobencenos
/
Exposición a Riesgos Ambientales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Pediatr
Año:
2016
Tipo del documento:
Article