The underlying mechanism of proinflammatory NF-&#954;B activation by the mTORC2/Akt/IKK&#945; pathway during skin aging.

Choi, Yeon Ja; Moon, Kyoung Mi; Chung, Ki Wung; Jeong, Ji Won; Park, Daeui; Kim, Dae Hyun; Yu, Byung Pal; Chung, Hae Young

The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging.

Choi, Yeon Ja; Moon, Kyoung Mi; Chung, Ki Wung; Jeong, Ji Won; Park, Daeui; Kim, Dae Hyun; Yu, Byung Pal; Chung, Hae Young.

Afiliación

Choi YJ; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.
Moon KM; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.
Chung KW; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.
Jeong JW; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.
Park D; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.
Kim DH; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, Korea.
Yu BP; Human and Environmental Toxicology, School of Engineering, University of Science and Technology, Daejeon, Korea.
Chung HY; Molecular Inflammation Research Center for Aging Intervention, College of Pharmacy, Pusan National University, Busan, Korea.

Oncotarget ; 7(33): 52685-52694, 2016 Aug 16.

Article en En | MEDLINE | ID: mdl-27486771

Asunto(s)

Quinasa I-kappa B/metabolismo; Diana Mecanicista del Complejo 2 de la Rapamicina/metabolismo; FN-kappa B/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Envejecimiento de la Piel; Animales; Línea Celular; Humanos; Inflamación/genética; Inflamación/metabolismo; Queratinocitos/metabolismo; Queratinocitos/efectos de la radiación; Masculino; Ratones Endogámicos C57BL; Fosforilación/efectos de la radiación; Transducción de Señal/efectos de la radiación; Piel/metabolismo; Piel/efectos de la radiación; Rayos Ultravioleta

Palabras clave

Gerotarget; NF-κB; UV; mTORC2; skin aging

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel / FN-kappa B / Quinasa I-kappa B / Proteínas Proto-Oncogénicas c-akt / Diana Mecanicista del Complejo 2 de la Rapamicina Límite: Animals / Humans / Male Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article

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