Cellular Delivery of RNA Nanoparticles.
ACS Comb Sci
; 18(9): 527-47, 2016 09 12.
Article
en En
| MEDLINE
| ID: mdl-27509068
ABSTRACT
RNA nanostructures can be programmed to exhibit defined sizes, shapes and stoichiometries from naturally occurring or de novo designed RNA motifs. These constructs can be used as scaffolds to attach functional moieties, such as ligand binding motifs or gene expression regulators, for nanobiology applications. This review is focused on four areas of importance to RNA nanotechnology the types of RNAs of particular interest for nanobiology, the assembly of RNA nanoconstructs, the challenges of cellular delivery of RNAs in vivo, and the delivery carriers that aid in the matter. The available strategies for the design of nucleic acid nanostructures, as well as for formulation of their carriers, make RNA nanotechnology an important tool in both basic research and applied biomedical science.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN
/
Sistemas de Liberación de Medicamentos
/
Nanopartículas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Comb Sci
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos