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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution.
Penman, Bridget S; Moffett, Ashley; Chazara, Olympe; Gupta, Sunetra; Parham, Peter.
Afiliación
  • Penman BS; Department of Zoology, University of Oxford, Tinbergen Building, South Parks Road, Oxford, OX13PS, UK. bridget.penman@zoo.ox.ac.uk.
  • Moffett A; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
  • Chazara O; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
  • Gupta S; Department of Zoology, University of Oxford, Tinbergen Building, South Parks Road, Oxford, OX13PS, UK.
  • Parham P; Department of Structural Biology, Stanford University, Stanford, CA, 94035, USA.
Immunogenetics ; 68(10): 755-764, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27517293
Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Haplotipos / Células Asesinas Naturales / Evolución Molecular / Receptores KIR / Infecciones Límite: Humans Idioma: En Revista: Immunogenetics Año: 2016 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Haplotipos / Células Asesinas Naturales / Evolución Molecular / Receptores KIR / Infecciones Límite: Humans Idioma: En Revista: Immunogenetics Año: 2016 Tipo del documento: Article
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