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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
Bradbury, Robert H; Callis, Rowena; Carr, Gregory R; Chen, Huawei; Clark, Edwin; Feron, Lyman; Glossop, Steve; Graham, Mark A; Hattersley, Maureen; Jones, Chris; Lamont, Scott G; Ouvry, Gilles; Patel, Anil; Patel, Joe; Rabow, Alfred A; Roberts, Craig A; Stokes, Stephen; Stratton, Natalie; Walker, Graeme E; Ward, Lara; Whalley, David; Whittaker, David; Wrigley, Gail; Waring, Michael J.
Afiliación
  • Bradbury RH; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Callis R; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Carr GR; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Chen H; AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States.
  • Clark E; AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States.
  • Feron L; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Glossop S; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Graham MA; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Hattersley M; AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States.
  • Jones C; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Lamont SG; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Ouvry G; AstraZeneca , Chemin du Moulin de Vrilly, 51100 Reims, France.
  • Patel A; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Patel J; AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States.
  • Rabow AA; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Roberts CA; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Stokes S; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Stratton N; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Walker GE; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Ward L; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Whalley D; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Whittaker D; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Wrigley G; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
  • Waring MJ; AstraZeneca, Mereside , Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
J Med Chem ; 59(17): 7801-17, 2016 09 08.
Article en En | MEDLINE | ID: mdl-27528113
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Factores de Transcripción / Proteínas Nucleares / Compuestos Heterocíclicos con 2 Anillos / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Factores de Transcripción / Proteínas Nucleares / Compuestos Heterocíclicos con 2 Anillos / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido