Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype.

Al Ghouleh, Imad; Meijles, Daniel N; Mutchler, Stephanie; Zhang, Qiangmin; Sahoo, Sanghamitra; Gorelova, Anastasia; Henrich Amaral, Jefferson; Rodríguez, Andrés I; Mamonova, Tatyana; Song, Gyun Jee; Bisello, Alessandro; Friedman, Peter A; Cifuentes-Pagano, M Eugenia; Pagano, Patrick J

Al Ghouleh, Imad; Meijles, Daniel N; Mutchler, Stephanie; Zhang, Qiangmin; Sahoo, Sanghamitra; Gorelova, Anastasia; Henrich Amaral, Jefferson; Rodríguez, Andrés I; Mamonova, Tatyana; Song, Gyun Jee; Bisello, Alessandro; Friedman, Peter A; Cifuentes-Pagano, M Eugenia; Pagano, Patrick J.

Afiliación

Al Ghouleh I; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, Univers
Meijles DN; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Mutchler S; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Zhang Q; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Sahoo S; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Gorelova A; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Henrich Amaral J; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Rodríguez AI; Heart Institute, University of São Paulo School of Medicine, Brazil;
Mamonova T; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Song GJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260; Brain Science and Engineering Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Korea;
Bisello A; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Friedman PA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260; Department of Structural Biology, Unive
Cifuentes-Pagano ME; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260;
Pagano PJ; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15260; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260; pagano@pitt.edu.

Proc Natl Acad Sci U S A ; 113(36): E5308-17, 2016 09 06.

Article en En | MEDLINE | ID: mdl-27540115

Asunto(s)

ATPasas Asociadas con Actividades Celulares Diversas/metabolismo; ADN Helicasas/metabolismo; Hipertrofia/metabolismo; NADPH Oxidasa 1/genética; Fosfoproteínas/metabolismo; Proteínas/metabolismo; Intercambiadores de Sodio-Hidrógeno/metabolismo; ATPasas Asociadas con Actividades Celulares Diversas/genética; Proteínas Adaptadoras Transductoras de Señales; Angiotensina II/administración & dosificación; Angiotensina II/efectos adversos; Animales; ADN Helicasas/genética; Arteria Femoral/efectos de los fármacos; Arteria Femoral/metabolismo; Arteria Femoral/patología; Humanos; Hipertrofia/inducido químicamente; Hipertrofia/patología; Lipopolisacáridos/toxicidad; Ratones; Ratones Noqueados; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patología; NADPH Oxidasa 1/metabolismo; Estrés Oxidativo/efectos de los fármacos; Fosfoproteínas/genética; Proteínas/genética; Especies Reactivas de Oxígeno/metabolismo; Intercambiadores de Sodio-Hidrógeno/genética; Superóxidos/metabolismo; Vasoconstricción/efectos de los fármacos; Vasoconstricción/genética

Palabras clave

EBP50; NADPH oxidase; hypertrophy; smooth muscle; vascular tone

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Proteínas / Intercambiadores de Sodio-Hidrógeno / ADN Helicasas / ATPasas Asociadas con Actividades Celulares Diversas / NADPH Oxidasa 1 / Hipertrofia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article

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