The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus.
BMC Infect Dis
; 16(1): 443, 2016 08 23.
Article
en En
| MEDLINE
| ID: mdl-27553866
ABSTRACT
BACKGROUND:
Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).METHODS:
HCV patients from France (n = 30), Brazil (n = 20) and Australia (n = 20) were interviewed to investigate HCV-HRQL issues raised in the scientific literature and by treatment specialists. Interviews were recorded, transcribed and translated into English and French.RESULTS:
Fifteen content dimensions were derived from the qualitative analysis, refined and fitted to four domains (1) Physical Health included fatigue, pain, sleep, sexual impairment and physical activity; (2) Mental Health psychological distress, psychosocial impact, and cognition; (3) Social Health support, stigma, social activity, substance use; (4) TREATMENT management, side effects, and fear of treatment failure. The impact of some dimensions extended beyond their primary domain including physical activity, cognition, sleep, sexual impairment, and the three treatment dimensions. A bank of 300 items was constructed to reflect patient reports and, following expert review, reduced to a 72-item pilot questionnaire.CONCLUSION:
We present a conceptually valid multidimensional model of HCV-specific quality of life and the pilot survey instrument, PROQOL-HCV. The model is widely inclusive of the experience of hepatitis C and the first to include the treatment dimension.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
Problema de salud:
1_sistemas_informacao_saude
/
2_enfermedades_transmissibles
Asunto principal:
Psicometría
/
Calidad de Vida
/
Encuestas y Cuestionarios
/
Indicadores de Salud
/
Hepatitis C
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do sul
/
Brasil
/
Europa
/
Oceania
Idioma:
En
Revista:
BMC Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia