Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.

Doherty, Christine M; Visse, Robert; Dinakarpandian, Deendayal; Strickland, Dudley K; Nagase, Hideaki; Troeberg, Linda

Doherty, Christine M; Visse, Robert; Dinakarpandian, Deendayal; Strickland, Dudley K; Nagase, Hideaki; Troeberg, Linda.

Afiliación

Doherty CM; From the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom.
Visse R; From the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom.
Dinakarpandian D; the School of Computing and Engineering, University of Missouri, Kansas City, Missouri 64111, and.
Strickland DK; the University of Maryland School of Medicine, Baltimore, Maryland 21201.
Nagase H; From the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom.
Troeberg L; From the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United Kingdom, linda.troeberg@kennedy.ox.ac.uk.

J Biol Chem ; 291(42): 22160-22172, 2016 Oct 14.

Article en En | MEDLINE | ID: mdl-27582494

Asunto(s)

Neoplasias Óseas/metabolismo; Condrosarcoma/metabolismo; Endocitosis; Matriz Extracelular/metabolismo; Proteínas de Neoplasias/metabolismo; Inhibidor Tisular de Metaloproteinasa-3/metabolismo; Proteína ADAMTS5/genética; Proteína ADAMTS5/metabolismo; Neoplasias Óseas/genética; Neoplasias Óseas/patología; Cartílago/metabolismo; Cartílago/patología; Línea Celular Tumoral; Condrosarcoma/genética; Condrosarcoma/patología; Matriz Extracelular/genética; Matriz Extracelular/patología; Heparina/metabolismo; Humanos; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/genética; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/metabolismo; Proteínas de Neoplasias/genética; Inhibidor Tisular de Metaloproteinasa-3/genética

Palabras clave

ADAM; ADAMTS; extracellular matrix; glycosaminoglycan; low-density lipoprotein receptor-related protein 1; osteoarthritis; receptor; tissue inhibitor of metalloproteinase (TIMP)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Condrosarcoma / Inhibidor Tisular de Metaloproteinasa-3 / Endocitosis / Matriz Extracelular / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

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