Mass production of functional human pancreatic ß-cells: why and how?
Diabetes Obes Metab
; 18 Suppl 1: 128-36, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27615142
ABSTRACT
Diabetes (either type 1 or type 2) is due to insufficient functional ß-cell mass. Research has, therefore, aimed to discover new ways to maintain or increase either ß-cell mass or function. For this purpose, rodents have mainly been used as model systems and a large number of discoveries have been made. Meanwhile, although we have learned that rodent models represent powerful systems to model ß-cell development, function and destruction, we realize that there are limitations when attempting to transfer the data to what is occurring in humans. Indeed, while human ß-cells share many similarities with rodent ß-cells, they also differ on a number of important parameters. In this context, developing ways to study human ß-cell development, function and death represents an important challenge. This review will describe recent data on the development and use of convenient sources of human ß-cells that should be useful tools to discover new ways to modulate functional ß-cell mass in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Técnicas de Cultivo de Célula
/
Diabetes Mellitus
/
Células Secretoras de Insulina
/
Células Madre Embrionarias Humanas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Diabetes Obes Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia