Chemical constituents from Cordia alliodora and C. colloccoca (Boraginaceae) and their biological activities.
Fitoterapia
; 115: 9-14, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-27659390
ABSTRACT
Two new natural products, 5-O-[ß-D-apiofuranosyl-(1â6)-ß-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). The isolated secondary metabolites were assayed for their antimicrobial activities against a panel of 6g positive and negative bacteria and three human pathogenic fungi. Moreover, their antiproliferative effect was also evaluated in vitro against the human non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid lung cancer cell line A549 as well as the normal human skin fibroblast cell line (AG01523).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Cordia
/
Indoles
Límite:
Humans
Idioma:
En
Revista:
Fitoterapia
Año:
2016
Tipo del documento:
Article
País de afiliación:
Grecia