Nucleus prepositus hypoglossi lesions produce a unique ocular motor syndrome.
Neurology
; 87(19): 2026-2033, 2016 Nov 08.
Article
en En
| MEDLINE
| ID: mdl-27733568
ABSTRACT
OBJECTIVE:
To describe the ocular motor abnormalities in 9 patients with a lesion involving the nucleus prepositus hypoglossi (NPH), a key constituent of a vestibular-cerebellar-brainstem neural network that ensures that the eyes are held steady in all positions of gaze.METHODS:
We recorded eye movements, including the vestibulo-ocular reflex during head impulses, in patients with vertigo and a lesion involving the NPH.RESULTS:
Our patients showed an ipsilesional-beating spontaneous nystagmus, horizontal gaze-evoked nystagmus more intense on looking toward the ipsilesional side, impaired pursuit more to the ipsilesional side, central patterns of head-shaking nystagmus, contralateral eye deviation, and decreased vestibulo-ocular reflex gain during contralesionally directed head impulses.CONCLUSIONS:
We attribute these findings to an imbalance in the NPH-inferior olive-flocculus-vestibular nucleus loop, and the ocular motor abnormalities provide a new brainstem localization for patients with acute vertigo.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleos Vestibulares
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Trastornos de la Motilidad Ocular
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Nistagmo Patológico
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Nervio Hipogloso
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurology
Año:
2016
Tipo del documento:
Article