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Multidisciplinary management of hepatoblastoma in children: Experience from a developing country.
Shanmugam, Naresh; Scott, Julius Xavier; Kumar, Vimal; Vij, Mukul; Ramachandran, Priya; Narasimhan, Gomathy; Reddy, Mettu Srinivas; Kota, Venugopal; Munirathnam, Deenadayalan; Kelgeri, Chayarani; Sundaram, Karthick; Rela, Mohamed.
Afiliación
  • Shanmugam N; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Global Health City, Chennai, Tamil Nadu, India.
  • Scott JX; Department of Pediatric Hematology and Oncology, Global Health City, Chennai, Tamil Nadu, India.
  • Kumar V; Department of Pediatric Hematology and Oncology, Global Health City, Chennai, Tamil Nadu, India.
  • Vij M; Department of Histopathology, Global Health City, Chennai, Tamil Nadu, India.
  • Ramachandran P; Institute of Liver Diseases & Transplantation, Global Health City, Chennai, Tamil Nadu, India.
  • Narasimhan G; Institute of Liver Diseases & Transplantation, Global Health City, Chennai, Tamil Nadu, India.
  • Reddy MS; Institute of Liver Diseases & Transplantation, Global Health City, Chennai, Tamil Nadu, India.
  • Kota V; Institute of Liver Diseases & Transplantation, Global Health City, Chennai, Tamil Nadu, India.
  • Munirathnam D; Department of Histopathology, Global Health City, Chennai, Tamil Nadu, India.
  • Kelgeri C; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Global Health City, Chennai, Tamil Nadu, India.
  • Sundaram K; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Global Health City, Chennai, Tamil Nadu, India.
  • Rela M; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Global Health City, Chennai, Tamil Nadu, India.
Pediatr Blood Cancer ; 64(3)2017 03.
Article en En | MEDLINE | ID: mdl-27781375
BACKGROUND: Advances in chemotherapy, liver resection techniques, and pediatric liver transplantation have vastly improved survival in children with hepatoblastoma (HB). These are best managed by a multidisciplinary team (MDT) in a setting where all treatment options are available. Until recently, this was difficult to achieve in India. METHODS: All children (<16 years) with HB treated in a pediatric liver surgery and transplantation unit between January 2011 and July 2016 were reviewed. Data regarding the clinical presentation, preoperative management, surgical treatment, postoperative course, and outcomes were extracted from a prospectively managed database. RESULTS: Thirty children were treated for HB during the study period. Nine children were PRETEXT 4, 7 were PRETEXT 3, 13 were PRETEXT 2, and 1 was PRETEXT 1 (where PRETEXT is pretreatment extension). All children received a neoadjuvant chemotherapy before surgery followed by an adjuvant chemotherapy. Nineteen children had complete resection, while six underwent primary living donor liver transplantation. There were six mortalities including five children who poorly responded to chemotherapy with progressive tumor extension. At a median follow-up of 30 months, two children who underwent resection and one child who underwent liver transplant had disease recurrence. CONCLUSION: Improved outcomes can be achieved in children with HB even in countries with limited resources when they are managed by MDTs with expertise in pediatric oncology, liver resection, and liver transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Hígado / Hepatoblastoma / Terapia Neoadyuvante / Hepatectomía / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Hígado / Hepatoblastoma / Terapia Neoadyuvante / Hepatectomía / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: India
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