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Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines.
Yang, Ziqi; Lu, Ning; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Duan, Haifeng; Lin, Yingjie.
Afiliación
  • Yang Z; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Lu N; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Wei Z; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Cao J; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Liang D; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Duan H; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
  • Lin Y; Department of Organic Chemistry, College of Chemistry, Jilin University , Changchun 130012, P. R. China.
J Org Chem ; 81(23): 11950-11955, 2016 12 02.
Article en En | MEDLINE | ID: mdl-27802591
ABSTRACT
We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo[2,1-a]isoquinolines. A number of pyrrolo[2,1-a]isoquinolines were synthesized in moderate to high yields (up to 97%).
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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article