Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism.
Alcohol Clin Exp Res
; 40(12): 2474-2481, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27805256
ABSTRACT
Alcohol is the most socially accepted addictive drug. Alcohol consumption is associated with some health problems such as neurological, cognitive, behavioral deficits, cancer, heart, and liver disease. Mechanisms of alcohol-induced toxicity are presently not yet clear. One of the mechanisms underlying alcohol toxicity has to do with its interaction with amino acid homocysteine (Hcy), which has been linked with brain neurotoxicity. Elevated Hcy impairs with various physiological mechanisms in the body, especially metabolic pathways. Hcy metabolism is predominantly controlled by epigenetic regulation such as DNA methylation, histone modifications, and acetylation. An alteration in these processes leads to epigenetic modification. Therefore, in this review, we summarize the role of Hcy metabolism abnormalities in alcohol-induced toxicity with epigenetic adaptation and their influences on cerebrovascular pathology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hiperhomocisteinemia
/
Epigénesis Genética
/
Etanol
/
Alcoholismo
/
Redes y Vías Metabólicas
/
Homocisteína
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Alcohol Clin Exp Res
Año:
2016
Tipo del documento:
Article