The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.
Altern Lab Anim
; 44(5): 453-460, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27805828
ABSTRACT
This article outlines the work of the Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded the 2015 Lush Black Box Prize. The award-winning work centred on the development of 'The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins'. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Recent developments in integrated approaches to testing and assessment, based on the AOP, are summarised. The impact of the AOP on regulatory policy and on the Three Rs are discussed. An overview of the next generation of the skin sensitisation AOP module in the OECD QSAR Toolbox, based on more-recent work at the Laboratory of Mathematical Chemistry, is also presented.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Toxicidad
/
Dermatitis por Contacto
/
Alternativas a las Pruebas en Animales
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Altern Lab Anim
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos