Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.

Bozzi, Aaron T; Bane, Lukas B; Weihofen, Wilhelm A; Singharoy, Abhishek; Guillen, Eduardo R; Ploegh, Hidde L; Schulten, Klaus; Gaudet, Rachelle

Bozzi, Aaron T; Bane, Lukas B; Weihofen, Wilhelm A; Singharoy, Abhishek; Guillen, Eduardo R; Ploegh, Hidde L; Schulten, Klaus; Gaudet, Rachelle.

Afiliación

Bozzi AT; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.
Bane LB; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.
Weihofen WA; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.
Singharoy A; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Guillen ER; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Ploegh HL; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Schulten K; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Gaudet R; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA. Electronic address: gaudet@mcb.harvard.edu.

Structure ; 24(12): 2102-2114, 2016 12 06.

Article en En | MEDLINE | ID: mdl-27839948

Asunto(s)

Proteínas de Transporte de Catión/química; Proteínas de Transporte de Catión/genética; Deinococcus/metabolismo; Metales/metabolismo; Proteínas Bacterianas/química; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Sitios de Unión; Proteínas de Transporte de Catión/metabolismo; Cristalografía por Rayos X; Deinococcus/genética; Modelos Moleculares; Mutación; Unión Proteica

Palabras clave

LeuT fold; MntH; Nramp; crystallography; cysteine accessibility; divalent metal transporter; microcytic anemia; natural resistance-associated macrophage protein; transition metals

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Catión / Deinococcus / Metales Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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