The sacral autonomic outflow is sympathetic.
Science
; 354(6314): 893-897, 2016 11 18.
Article
en En
| MEDLINE
| ID: mdl-27856909
ABSTRACT
A kinship between cranial and pelvic visceral nerves of vertebrates has been accepted for a century. Accordingly, sacral preganglionic neurons are considered parasympathetic, as are their targets in the pelvic ganglia that prominently control rectal, bladder, and genital functions. Here, we uncover 15 phenotypic and ontogenetic features that distinguish pre- and postganglionic neurons of the cranial parasympathetic outflow from those of the thoracolumbar sympathetic outflow in mice. By every single one, the sacral outflow is indistinguishable from the thoracolumbar outflow. Thus, the parasympathetic nervous system receives input from cranial nerves exclusively and the sympathetic nervous system from spinal nerves, thoracic to sacral inclusively. This simplified, bipartite architecture offers a new framework to understand pelvic neurophysiology as well as development and evolution of the autonomic nervous system.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sacro
/
Sistema Nervioso Simpático
/
Ganglios Simpáticos
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2016
Tipo del documento:
Article