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Extra views on structure and dynamics of DNA loops on nucleosomes studied with molecular simulations.
Pasi, Marco; Angelov, Dimitar; Bednar, Jan; Dimitrov, Stefan; Lavery, Richard.
Afiliación
  • Pasi M; a Université de Lyon/CNRS UMR 5086, MMSB, Institut de Biologie et Chimie des Protéines , Lyon , France.
  • Angelov D; b Université de Lyon/CNRS/INRA UMR 5239, LBMC, Ecole Normale Supérieure de Lyon , Lyon , France.
  • Bednar J; c Institut Albert Bonniot, Université de Grenoble Alpes/INSERM U1209/CNRS UMR 5309 , Grenoble , France.
  • Dimitrov S; c Institut Albert Bonniot, Université de Grenoble Alpes/INSERM U1209/CNRS UMR 5309 , Grenoble , France.
  • Lavery R; a Université de Lyon/CNRS UMR 5086, MMSB, Institut de Biologie et Chimie des Protéines , Lyon , France.
Nucleus ; 7(6): 554-559, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27874316
ABSTRACT
It has been shown experimentally that the action of the RSC chromatin remodeler leads to the formation of an irregular, partially remodeled nucleosome, termed a remosome. The remosome contains an extra 30-40 base pairs of DNA compared to a canonical nucleosome. Large-scale molecular simulations have provided information on the probable structure of remosomes and have explained why they remain stable in the absence of RSC. Here we explain how these simulations were carried out and what the resulting remosome models imply in terms of the mechanism of action of RSC. We notably show that local kinks within DNA are key in explaining how extra DNA can be in added to nucleosomes without unduly disturbing DNA-histone binding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Nucleosomas / Modelos Moleculares Idioma: En Revista: Nucleus Año: 2016 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Nucleosomas / Modelos Moleculares Idioma: En Revista: Nucleus Año: 2016 Tipo del documento: Article País de afiliación: Francia
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