Design of artificial red blood cells using polymeric hydrogel microcapsules: hydrogel stability improvement and polymer selection.
Int J Artif Organs
; 39(10): 518-523, 2016 10 01.
Article
en En
| MEDLINE
| ID: mdl-27886350
ABSTRACT
PURPOSE:
To improve the stability of pectin-oligochitosan hydrogel microcapsules under physiological conditions.METHODS:
Two different approaches were examined change of the cross-linker length and treatment of the hydrogel microcapsules with 150 Mm CaCl2. Replacement of pectin with alginate was also studied. RESULTS ANDCONCLUSIONS:
It was observed that the molecular weight of the cross-linker oligochiotsan had no significant improvement on microcapsule stability. On the other hand, the treatment of pectin-oligochitosan microcapsules with Ca2+ increased the microcapsule stability significantly. Different types of alginate were used; however, no red-blood-cell-shaped microcapsules could be produced, which is likely due to the charge-density difference between deprotonated pectin and alginate polymers.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Int J Artif Organs
Año:
2016
Tipo del documento:
Article