The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.
FEBS Lett
; 591(1): 145-154, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-27926990
ABSTRACT
F-box proteins play pivotal roles in multiple cellular processes; however, little is known about their functions in glioma progression. In this study, we found that expression of the F-box and leucine-rich repeat protein 18 (FBXL18) is significantly upregulated in glioma tissues. Depletion of FBXL18 in glioma cells suppresses proliferation and anchorage-independent cell growth, and promotes apoptosis. We also demonstrate that depletion of FBXL18 significantly inhibits Akt activity and the phosphorylation of FOXO3a, which leads to upregulation of BCL2L11. Further mechanistic analyses indicate that FBXL18 promotes the K63-linked ubiquitination of Akt, which is required for its activation. Taken together, our results suggest that FBXL18 plays an oncogenic role through promoting K63-linked ubiquitination of Akt in glioma.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_brain_nervous_system_cancer
Asunto principal:
Progresión de la Enfermedad
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Proteínas F-Box
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Proteínas Proto-Oncogénicas c-akt
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Ubiquitinación
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Glioma
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Lisina
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2017
Tipo del documento:
Article
País de afiliación:
China