To use or not to use the force: How B lymphocytes extract surface-tethered antigens.
J Cell Biol
; 216(1): 17-19, 2017 01 02.
Article
en En
| MEDLINE
| ID: mdl-27998992
ABSTRACT
Using an exquisite cell imaging approach based on DNA nanosensors, Spillane and Tolar (2016. J. Cell Biol. https//doi.org/10.1083/jcb.201607064) explore how the physical properties of antigen-presenting cell surfaces affect how B cells internalize surface-tethered antigens. Soft and flexible surfaces promote mechanical force-mediated antigen extraction, whereas stiff surfaces lead to enzyme-mediated antigen release before subsequent internalization.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos B
/
Antígenos de Superficie
Límite:
Humans
Idioma:
En
Revista:
J Cell Biol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia