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{Fe(NO)(2)(9) Dinitrosyl Iron Complex Acting as a Vehicle for the NO Radical.
Ke, Chun-Hung; Chen, Chien-Hong; Tsai, Ming-Li; Wang, Hsuan-Chi; Tsai, Fu-Te; Chiang, Yun-Wei; Shih, Wei-Chih; Bohle, D Scott; Liaw, Wen-Feng.
Afiliación
  • Ke CH; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
  • Chen CH; Department of Medical Applied Chemistry, Chung Shan Medical University, and Department of Medical Education, Chung Shan Medical University Hospital , Taichung 40201, Taiwan.
  • Tsai ML; Department of Chemistry, National Sun Yat-sen University , Kaohsiung 80424, Taiwan.
  • Wang HC; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
  • Tsai FT; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
  • Chiang YW; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
  • Shih WC; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
  • Bohle DS; Department of Chemistry, McGill University 801 Sherbrooke Street West, Montreal, Quebec H3A2K6, Canada.
  • Liaw WF; Department of Chemistry and Frontier Research Center of Fundamental and Applied Science of Matters, National Tsing Hua University , Hsinchu 30013, Taiwan.
J Am Chem Soc ; 139(1): 67-70, 2017 01 11.
Article en En | MEDLINE | ID: mdl-28030770
ABSTRACT
To carry and deliver nitric oxide with a controlled redox state and rate is crucial for its pharmaceutical/medicinal applications. In this study, the capability of cationic {Fe(NO)2}9 dinitrosyl iron complexes (DNICs) [(RDDB)Fe(NO)2]+ (R = Me, Et, Iso; RDDB = N,N'-bis(2,6-dialkylphenyl)-1,4-diaza-2,3-dimethyl-1,3-butadiene) carrying nearly unperturbed nitric oxide radical to form [(RDDB)Fe(NO)2(•NO)]+ was demonstrated and characterized by IR, UV-vis, EPR, NMR, and single-crystal X-ray diffractions. The unique triplet ground state of [(RDDB)Fe(NO)2(•NO)]+ results from the ferromagnetic coupling between two strictly orthogonal orbitals, one from Fe dz2 and the other a π*op orbital of a unique bent axial NO ligand, which is responsible for the growth of a half-field transition (ΔMS = 2) from 70 to 4 K in variable-temperature EPR measurements. Consistent with the NO radical character of coordinated axial NO ligand in complex [(MeDDB)Fe(NO)2(•NO)]+, the simple addition of MeCN/H2O into CH2Cl2 solution of complexes [(RDDB)Fe(NO)2(•NO)]+ at 25 °C released NO as a neutral radical, as demonstrated by the formation of [S5Fe(NO)2]- from [S5Fe(µ-S)2FeS5]2-.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hierro / Óxido Nítrico / Óxidos de Nitrógeno Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hierro / Óxido Nítrico / Óxidos de Nitrógeno Idioma: En Revista: J Am Chem Soc Año: 2017 Tipo del documento: Article País de afiliación: Taiwán