RAIN: RNA-protein Association and Interaction Networks.
Database (Oxford)
; 20172017.
Article
en En
| MEDLINE
| ID: mdl-28077569
ABSTRACT
Protein association networks can be inferred from a range of resources including experimental data, literature mining and computational predictions. These types of evidence are emerging for non-coding RNAs (ncRNAs) as well. However, integration of ncRNAs into protein association networks is challenging due to data heterogeneity. Here, we present a database of ncRNA-RNA and ncRNA-protein interactions and its integration with the STRING database of protein-protein interactions. These ncRNA associations cover four organisms and have been established from curated examples, experimental data, interaction predictions and automatic literature mining. RAIN uses an integrative scoring scheme to assign a confidence score to each interaction. We demonstrate that RAIN outperforms the underlying microRNA-target predictions in inferring ncRNA interactions. RAIN can be operated through an easily accessible web interface and all interaction data can be downloaded.Database URL http//rth.dk/resources/rain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interfaz Usuario-Computador
/
Proteínas de Unión al ARN
/
Bases de Datos Genéticas
/
MicroARNs
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Database (Oxford)
Año:
2017
Tipo del documento:
Article
País de afiliación:
Dinamarca