An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.
Nat Plants
; 3: 16208, 2017 01 13.
Article
en En
| MEDLINE
| ID: mdl-28085153
ABSTRACT
Plants sequester intermediates of metabolic pathways into different cellular compartments, but the mechanisms by which these molecules are transported remain poorly understood. Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in several different cellular locations. However, the transporters that control the movement of these biosynthetic intermediates within cellular compartments have not been discovered. Here we present the discovery of a tonoplast localized nitrate/peptide family (NPF) transporter from Catharanthus roseus, CrNPF2.9, that exports strictosidine, the central intermediate of this pathway, into the cytosol from the vacuole. This discovery highlights the role that intracellular localization plays in specialized metabolism, and sets the stage for understanding and controlling the central branch point of this pharmacologically important group of compounds.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Plantas
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Alcaloides de la Vinca
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Regulación de la Expresión Génica de las Plantas
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Catharanthus
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Proteínas de Transporte de Anión
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Simportadores
Idioma:
En
Revista:
Nat Plants
Año:
2017
Tipo del documento:
Article
País de afiliación:
Reino Unido