The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages.
Emerg Microbes Infect
; 6(1): e4, 2017 Jan 18.
Article
en En
| MEDLINE
| ID: mdl-28096531
ABSTRACT
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fiebre del Valle del Rift
/
Virus de la Fiebre del Valle del Rift
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Variación Genética
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Virus Reordenados
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Genoma Viral
Límite:
Animals
/
Humans
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Middle aged
País/Región como asunto:
Africa
/
Asia
Idioma:
En
Revista:
Emerg Microbes Infect
Año:
2017
Tipo del documento:
Article
País de afiliación:
China