Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.
Tetrahedron Lett
; 58(7): 642-644, 2017 02 15.
Article
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| MEDLINE
| ID: mdl-28163339
ABSTRACT
Herein, we report the synthesis of novel 2',2',3',3'-tetrafluorinated nucleoside analogs along with their phosphoramidate prodrugs. A tetrafluoro ribose moiety was coupled with different Boc/benzoyl-protected nucleobases under Mitsunobu conditions. After deprotection, tetrafluorinated nucleosides 13b, 14b, 20b-22b were reacted with phenyl-(isopropoxy-L-alaninyl)-phosphorochloridate to afford corresponding monophosphate prodrugs 24b-28b. All synthesized compounds were evaluated against several DNA and RNA viruses including HIV, HBV, HCV, Ebola and Zika viruses.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos