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A new LC-MS/MS bioanalytical method for atenolol in human plasma and milk.
Phyo Lwin, Ei Mon; Gerber, Cobus; Song, Yunmei; Leggett, Catherine; Ritchie, Usha; Turner, Sean; Garg, Sanjay.
Afiliación
  • Phyo Lwin EM; School of Pharmacy & Medical Sciences, Reid Building, City East Campus, University of South Australia, Adelaide, SA 5000, Australia.
  • Gerber C; School of Pharmacy & Medical Sciences, Reid Building, City East Campus, University of South Australia, Adelaide, SA 5000, Australia.
  • Song Y; School of Pharmacy & Medical Sciences, Reid Building, City East Campus, University of South Australia, Adelaide, SA 5000, Australia.
  • Leggett C; Women's & Children's Hospital, SA Pharmacy, Adelaide, SA 5006, Australia.
  • Ritchie U; Women's & Children's Hospital, SA Pharmacy, Adelaide, SA 5006, Australia.
  • Turner S; Women's & Children's Hospital, SA Pharmacy, Adelaide, SA 5006, Australia.
  • Garg S; School of Pharmacy & Medical Sciences, Reid Building, City East Campus, University of South Australia, Adelaide, SA 5000, Australia.
Bioanalysis ; 9(7): 517-530, 2017 Apr.
Article en En | MEDLINE | ID: mdl-28300420
ABSTRACT

AIM:

A new sensitive LC-MS/MS method for the quantification of atenolol in human plasma and milk has been developed for clinical lactation studies. METHODS &

RESULTS:

Atenolol and the internal standard, phenazone, were extracted from biological matrices by protein precipitation. A Phenomenex® C-18 column and gradient chromatographic conditions were used for separation of the analyte, followed by detection with MS. Stability of samples was confirmed for atenolol in human plasma and milk for up to 3 months. Linearity range of 1-800 ng/ml (r2 = 0.9995), the precision within 15% CV and the recovery of the analyte (80-100% range) were achieved.

CONCLUSION:

A new validated analytical method for atenolol in plasma and milk was developed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Atenolol / Cromatografía Liquida / Leche / Espectrometría de Masas en Tándem Límite: Animals / Humans Idioma: En Revista: Bioanalysis Año: 2017 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Atenolol / Cromatografía Liquida / Leche / Espectrometría de Masas en Tándem Límite: Animals / Humans Idioma: En Revista: Bioanalysis Año: 2017 Tipo del documento: Article País de afiliación: Australia