[Autoantibodies in systemic connective tissue disease and ANCA-associated vasculitis, their relationship to interstitial lung diseases and prognosis]. / Autoprotilátky u systémových onemocnení pojiva a ANCA asociovaných vaskulitid, jejich vztah k intersticiálním plicním procesum a prognóze.

ABSTRACT

Lung disease, including interstitial lung disease (ILD), is a frequent complication of systemic connective tissue disorders (CTD) and ANCA (anti-neutrophil cytoplasmic antibody) associated vasculitis (AAV). Pulmonary manifestations are prognostic factor of CTDs and vasculitis. Autoantibodies assessment is a part of differential diagnosis algorithm of lung diseases. Autoantibodies importance is mainly clinical-diagnostic. Using detection of some autoantibodies it is possible to determine prognosis of lung involvement, especially in CTDs.Key words autoantibodies - connective tissue disease - interstitial lung diseases - prognosis - vasculitis.