Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound.
Bull Exp Biol Med
; 162(5): 636-639, 2017 Mar.
Article
en En
| MEDLINE
| ID: mdl-28361426
ABSTRACT
Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azepinas
/
Bencimidazoles
/
Trombosis de las Arterias Carótidas
/
Fibrinolíticos
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Rusia