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Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound.
Spasov, A A; Kucheryavenko, A F; Sirotenko, V S; Gaidukova, K A; Morkovnik, A S; Anisimova, V A; Divaeva, L N; Kuz'menko, T A.
Afiliación
  • Spasov AA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Kucheryavenko AF; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. aidakucheryavenko@yandex.ru.
  • Sirotenko VS; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Gaidukova KA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
  • Morkovnik AS; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
  • Anisimova VA; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
  • Divaeva LN; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
  • Kuz'menko TA; Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
Bull Exp Biol Med ; 162(5): 636-639, 2017 Mar.
Article en En | MEDLINE | ID: mdl-28361426
ABSTRACT
Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Bencimidazoles / Trombosis de las Arterias Carótidas / Fibrinolíticos Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2017 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Azepinas / Bencimidazoles / Trombosis de las Arterias Carótidas / Fibrinolíticos Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2017 Tipo del documento: Article País de afiliación: Rusia