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Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice.
Yin, Xiaomin; Jin, Nana; Shi, Jianhua; Zhang, Yanchong; Wu, Yue; Gong, Cheng-Xin; Iqbal, Khalid; Liu, Fei.
Afiliación
  • Yin X; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA.
  • Jin N; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226001, P. R. China.
  • Shi J; Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P. R. China.
  • Zhang Y; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA.
  • Wu Y; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226001, P. R. China.
  • Gong CX; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA.
  • Iqbal K; Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226001, P. R. China.
  • Liu F; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA.
Sci Rep ; 7(1): 619, 2017 04 04.
Article en En | MEDLINE | ID: mdl-28377597
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Regulación de la Expresión Génica / Proteínas tau / Proteínas Serina-Treonina Quinasas / Síndrome de Down / Disfunción Cognitiva Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Regulación de la Expresión Génica / Proteínas tau / Proteínas Serina-Treonina Quinasas / Síndrome de Down / Disfunción Cognitiva Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos