Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.

Liu, Fuchen; Wang, Guangyong; Wang, Xiaoqiang; Che, Zhihui; Dong, Wei; Guo, Xinggang; Wang, Zhenguang; Chen, Ping; Hou, Daisen; Zhang, Qi; Zhang, Wenli; Pan, Yida; Yang, Dongqin; Liu, Hui

Liu, Fuchen; Wang, Guangyong; Wang, Xiaoqiang; Che, Zhihui; Dong, Wei; Guo, Xinggang; Wang, Zhenguang; Chen, Ping; Hou, Daisen; Zhang, Qi; Zhang, Wenli; Pan, Yida; Yang, Dongqin; Liu, Hui.

Afiliación

Liu F; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Wang G; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Wang X; Department of Gastroenterology, 411 Hospital of PLA, Shanghai 200081, China.
Che Z; Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
Dong W; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Guo X; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Wang Z; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Chen P; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Hou D; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Zhang Q; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Zhang W; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Pan Y; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Yang D; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.
Liu H; Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200032, China.

Oncotarget ; 8(17): 27953-27965, 2017 Apr 25.

Article en En | MEDLINE | ID: mdl-28427193

Asunto(s)

Aurora Quinasas/metabolismo; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; Adulto; Anciano; Apoptosis/efectos de los fármacos; Aurora Quinasa A/genética; Aurora Quinasa A/metabolismo; Aurora Quinasa B/genética; Aurora Quinasa B/metabolismo; Aurora Quinasas/antagonistas & inhibidores; Aurora Quinasas/genética; Biomarcadores de Tumor; Carcinoma Hepatocelular/tratamiento farmacológico; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/mortalidad; Proteínas de Ciclo Celular; Línea Celular Tumoral; Supervivencia Celular; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/mortalidad; Persona de Mediana Edad; Modelos Biológicos; Terapia Molecular Dirigida; Proteínas Nucleares/metabolismo; Compuestos de Fenilurea/farmacología; Poliploidía; Pronóstico; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico; Tiazoles/farmacología; Factores de Transcripción/metabolismo; Carga Tumoral

Palabras clave

Aurora A/B kinases; HCC; P21; SNS-314; YAP

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 6_ODS3_enfermedades_notrasmisibles Problema de salud: 6_congenital_chromosomal_anomalies / 6_digestive_diseases / 6_liver_cancer Asunto principal: Carcinoma Hepatocelular / Aurora Quinasas / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Oncotarget Año: 2017 Tipo del documento: Article País de afiliación: China

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