Design of Chemical Conjugate for Targeted Therapy of Multiple Sclerosis Based of Constant Fragment of Human Antibody Heavy Chain and Peptoid Analog of Autoantigen MOG35-55.
Bull Exp Biol Med
; 162(6): 777-780, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-28429225
ABSTRACT
Elimination of B cells producing autoantibodies to neuroantigens is considered as beneficial in the treatment of multiple sclerosis. Myelin oligodendrocyte glycoprotein (MOG) is a significant autoantigen in multiple sclerosis. It was shown that MOG-like peptoid AMogP3 can bind autoantibodies produced by pathological lymphocytes. We propose a structure of an innovative drug for targeted elimination of the pool of autoreactive B cells responsible for multiple sclerosis pathogenesis; this compound is a complex of peptoid AMogP3 with Fc fragment of human immunoglobulin. The obtained Fc-PEG-AMogP3 conjugate effectively interact with autoreactive antibodies, which attests to their high therapeutic potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
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Autoantígenos
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Fragmentos Fc de Inmunoglobulinas
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Cadenas Pesadas de Inmunoglobulina
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Inmunoconjugados
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Peptoides
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Glicoproteína Mielina-Oligodendrócito
Límite:
Humans
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Rusia