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Increased non-relapse mortality due to high-dose cytarabine plus CY/TBI in BMT/PBSCT for acute lymphoblastic leukaemia in adults.
Arai, Yasuyuki; Kondo, Tadakazu; Shigematsu, Akio; Tanaka, Junji; Ohashi, Kazuteru; Fukuda, Takahiro; Kawakita, Toshiro; Mori, Takehiko; Hoshino, Takumi; Onizuka, Makoto; Ozawa, Yukiyasu; Yoshida, Shuro; Ueda, Yasunori; Mizuno, Ishikazu; Atsuta, Yoshiko; Mizuta, Shuichi.
Afiliación
  • Arai Y; Department of Haematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kondo T; Laboratory of Host Defences, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Shigematsu A; Department of Haematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Tanaka J; Department of Haematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
  • Ohashi K; Department of Haematology, Tokyo Women's Medical University, Tokyo, Japan.
  • Fukuda T; Haematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Centre, Komagome Hospital, Tokyo, Japan.
  • Kawakita T; Department of Haematopoietic Stem Cell Transplantation, National Cancer Centre Hospital, Tokyo, Japan.
  • Mori T; Department of Haematology, National Hospital Organization Kumamoto Medical Centre, Kumamoto, Japan.
  • Hoshino T; Division of Haematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Onizuka M; Leukaemia Research Centre, Saiseikai Maebashi Hospital, Maebashi, Japan.
  • Ozawa Y; Department of Haematology/Oncology, Tokai University School of Medicine, Isehara, Japan.
  • Yoshida S; Department of Haematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
  • Ueda Y; Department of Haematology, Hamanomachi Hospital, Fukuoka, Japan.
  • Mizuno I; Department of Haematology/Oncology and Transfusion and Haemapheresis Centre, Kurashiki Central Hospital, Kurashiki, Japan.
  • Atsuta Y; Department of Haematology, Hyogo Cancer Centre, Akashi, Japan.
  • Mizuta S; Japanese Data Centre for Haematopoietic Cell Transplantation, Nagoya, Japan.
Br J Haematol ; 178(1): 106-111, 2017 07.
Article en En | MEDLINE | ID: mdl-28439877
ABSTRACT
The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT). In this cohort study, we compared the prognosis of CY/TBI (N = 1244) and HDCA/CY/TBI (N = 316) regimens in BMT/PBSCT for ALL. The addition of HDCA decreased post-transplant relapse, while significantly increasing non-relapse mortality (risk ratio, 1·33), and overall survival was not improved. The positive effects of HDCA reported in CBT cannot be extrapolated to BMT/PBSCT, and HDCA may not be recommended in these procedures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Médula Ósea / Acondicionamiento Pretrasplante / Citarabina / Trasplante de Células Madre de Sangre Periférica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Br J Haematol Año: 2017 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Médula Ósea / Acondicionamiento Pretrasplante / Citarabina / Trasplante de Células Madre de Sangre Periférica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Br J Haematol Año: 2017 Tipo del documento: Article País de afiliación: Japón