Assessment of the synergic effect of immunomodulation on nerve repair using multiparametric magnetic resonance imaging.
Muscle Nerve
; 57(1): E38-E45, 2018 Jan.
Article
en En
| MEDLINE
| ID: mdl-28445921
ABSTRACT
INTRODUCTION:
The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis.METHODS:
Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8-week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate-buffered saline (PBS) alone.RESULTS:
Nerves treated with immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS.DISCUSSION:
Nerves treated with immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. Muscle Nerve 57 E38-E45, 2018.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunomodulación
/
Traumatismos de los Nervios Periféricos
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2018
Tipo del documento:
Article
País de afiliación:
China