Virus population dynamics during infection.
Curr Opin Virol
; 23: 82-87, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-28456056
ABSTRACT
During RNA virus infection of a host, error-prone viral replication will give rise to a cloud of genetically-linked mutants, as well as truncated, defective genomes. In this review, we describe the dynamics of viral diversity during infection, illustrating that the viral population fluctuates greatly in number of genomes and composition of mutants, in relation with the existence of physical barriers or immune pressures. We illustrate the importance of generating diversity by analyzing the case of fidelity variants, largely attenuated in vivo. Recombination is also considered in its various roles redistribution of mutations on full-length genomes, and production of highly-immunostimulatory defective genomes. We cover these notions by underlining, when they exist, the differences between acute and persistent infections.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Virus ARN
/
Variación Genética
/
Virus
/
Dinámica Poblacional
Idioma:
En
Revista:
Curr Opin Virol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia