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Regional susceptibility to dose-dependent white matter damage after brain radiotherapy.
Connor, Michael; Karunamuni, Roshan; McDonald, Carrie; Seibert, Tyler; White, Nathan; Moiseenko, Vitali; Bartsch, Hauke; Farid, Nikdokht; Kuperman, Joshua; Krishnan, Anitha; Dale, Anders; Hattangadi-Gluth, Jona A.
Afiliación
  • Connor M; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States.
  • Karunamuni R; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • McDonald C; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Department of Psychiatry, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San
  • Seibert T; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • White N; Department of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • Moiseenko V; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States.
  • Bartsch H; Department of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • Farid N; Department of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • Kuperman J; Department of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • Krishnan A; Department of Radiology, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States.
  • Dale A; Department of Radiology, University of California San Diego, La Jolla, California, United States; Department of Psychiatry, University of California San Diego, La Jolla, California, United States; Department of Neurosciences, University of California San Diego, La Jolla, California, United States; C
  • Hattangadi-Gluth JA; Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California, United States. Electronic address: jhattangadi@ucsd.edu.
Radiother Oncol ; 123(2): 209-217, 2017 05.
Article en En | MEDLINE | ID: mdl-28460824
ABSTRACT
BACKGROUND AND

PURPOSE:

Regional differences in sensitivity to white matter damage after brain radiotherapy (RT) are not well-described. We characterized the spatial heterogeneity of dose-response across white matter tracts using diffusion tensor imaging (DTI). MATERIALS AND

METHODS:

Forty-nine patients with primary brain tumors underwent MRI with DTI before and 9-12months after partial-brain RT. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were generated. Atlas-based white matter tracts were identified. A secondary analysis using skeletonized tracts was also performed. Linear mixed-model analysis of the relationship between mean and max dose and percent change in DTI metrics was performed.

RESULTS:

Tracts with the strongest correlation of FA change with mean dose were the fornix (-0.46 percent/Gy), cingulum bundle (-0.44 percent/Gy), and body of corpus callosum (-0.23 percent/Gy), p<.001. These tracts also showed dose-sensitive changes in MD and RD. In the skeletonized analysis, the fornix and cingulum bundle remained highly dose-sensitive. Maximum and mean dose were similarly predictive of DTI change.

CONCLUSIONS:

The corpus callosum, cingulum bundle, and fornix show the most prominent dose-dependent changes following RT. Future studies examining correlation with cognitive functioning and potential avoidance of critical white matter regions are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Sustancia Blanca Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Radiother Oncol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Sustancia Blanca Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Radiother Oncol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos