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Malaria pigment stimulates chemokine production by human microvascular endothelium.
Basilico, Nicoletta; Corbett, Yolanda; D' Alessandro, Sarah; Parapini, Silvia; Prato, Mauro; Girelli, Daniela; Misiano, Paola; Olliaro, Piero; Taramelli, Donatella.
Afiliación
  • Basilico N; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy. Electronic address: nicoletta.basilico@unimi.it.
  • Corbett Y; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
  • D' Alessandro S; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
  • Parapini S; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
  • Prato M; Dipartimento di Neuroscienze Università di Torino, Corso Raffaello 30-10125, Torino, Italy.
  • Girelli D; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
  • Misiano P; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
  • Olliaro P; UNICEF/UNDP/World Bank/WHO Special Programme on Research & Training in Tropical Diseases (TDR) World Health Organization, Geneva, Switzerland; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, UK.
  • Taramelli D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Pascal 36-20133, Milano, Italy.
Acta Trop ; 172: 125-131, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28476599
Severe falciparum malaria is characterized by the sequestration of infected erythrocytes and leukocyte recruitment in the microvasculature, resulting in impaired blood flow and metabolic disturbances. Which parasite products cause chemokine production, thus contributing to the strong host inflammatory response and cellular recruitment are not well characterized. Here, we studied haemozoin (Hz), the end-product of haem, a ferriprotoporphyrin-IX crystal bound to host and parasite lipids, DNA, and proteins. We found that natural Hz isolated from Plasmodium falciparum cultures induces CXCL8 and CCL5 production in human dermal microvascular endothelial cells (HMEC-1) in a time-dependent manner. This up-regulation is not caused by haem but rather by Hz-generated lipoperoxidation products (15-HETE) and fibrinogen associated to Hz, and is, at least in part, triggered by the activation of NF-κB, as it was significantly inhibited by artemisinin and other NF-κB pathway inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases / 3_zoonosis Asunto principal: Plasmodium falciparum / Quimiocinas / Células Endoteliales Límite: Animals / Humans Idioma: En Revista: Acta Trop Año: 2017 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 3_ND Problema de salud: 2_enfermedades_transmissibles / 3_malaria / 3_neglected_diseases / 3_zoonosis Asunto principal: Plasmodium falciparum / Quimiocinas / Células Endoteliales Límite: Animals / Humans Idioma: En Revista: Acta Trop Año: 2017 Tipo del documento: Article
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