Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

Göckeritz, Elisa; Vondey, Verena; Guastafierro, Anna; Pizevska, Maja; Hassenrück, Floyd; Neumann, Lars; Hallek, Michael; Krause, Günter

Göckeritz, Elisa; Vondey, Verena; Guastafierro, Anna; Pizevska, Maja; Hassenrück, Floyd; Neumann, Lars; Hallek, Michael; Krause, Günter.

Afiliación

Göckeritz E; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Vondey V; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Guastafierro A; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Pizevska M; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Hassenrück F; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Neumann L; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Hallek M; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Krause G; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.

Br J Haematol ; 178(6): 949-953, 2017 09.

Article en En | MEDLINE | ID: mdl-28573668

Asunto(s)

Linfocitos B/enzimología; Leucemia de Células B/genética; Linfoma de Células B/genética; Proteínas Tirosina Quinasas/genética; Adenina/análogos & derivados; Agammaglobulinemia Tirosina Quinasa; Antineoplásicos; Quimiocinas/metabolismo; Quimiotaxis/efectos de los fármacos; Dasatinib/administración & dosificación; Dasatinib/farmacología; Relación Dosis-Respuesta a Droga; Resistencia a Antineoplásicos/genética; Humanos; Leucemia de Células B/enzimología; Leucemia de Células B/patología; Linfoma de Células B/enzimología; Linfoma de Células B/patología; Mutación; Fosforilación/efectos de los fármacos; Piperidinas; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Tirosina Quinasas/antagonistas & inhibidores; Proteínas Tirosina Quinasas/metabolismo; Pirazoles/administración & dosificación; Pirazoles/farmacología; Pirimidinas/administración & dosificación; Pirimidinas/farmacología; Células Tumorales Cultivadas

Palabras clave

B cell malignancies; chemokine secretion; chemotaxis; resistance mutations; tyrosine kinase inhibitors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Linfocitos B / Leucemia de Células B / Linfoma de Células B Límite: Humans Idioma: En Revista: Br J Haematol Año: 2017 Tipo del documento: Article País de afiliación: Alemania

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