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Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.
Zanotti, Stefano; Yu, Jungeun; Sanjay, Archana; Schilling, Lauren; Schoenherr, Chris; Economides, Aris N; Canalis, Ernesto.
Afiliación
  • Zanotti S; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030; Department of Medicine, UConn Health, Farmington, Connecticut 06030; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
  • Yu J; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
  • Sanjay A; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
  • Schilling L; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.
  • Schoenherr C; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Economides AN; Regeneron Pharmaceuticals, Tarrytown, New York 10591.
  • Canalis E; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030; Department of Medicine, UConn Health, Farmington, Connecticut 06030; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030. Electronic address: canalis@uchc.edu.
J Biol Chem ; 292(29): 12232-12244, 2017 07 21.
Article en En | MEDLINE | ID: mdl-28592489
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Enfermedades Óseas Metabólicas / Transducción de Señal / Síndrome de Hajdu-Cheney / Receptor Notch2 / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoblastos / Enfermedades Óseas Metabólicas / Transducción de Señal / Síndrome de Hajdu-Cheney / Receptor Notch2 / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article