Outcomes following indomethacin prophylaxis in extremely preterm infants in an all-referral NICU.
J Perinatol
; 37(8): 932-937, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28617424
ABSTRACT
OBJECTIVE:
We examined data from a contemporary cohort of extreme prematurity (EP) infants admitted to an all-referral Children's Hospital neonatal intensive care unit (NICU) to determine whether prophylactic indomethacin (PI) may continue to benefit these patients. STUDYDESIGN:
An observational study utilizing the small baby ICU data registry that was queried for all EP infants admitted between 2005 and 2014 with documentation of PI use (671 total EP infants; 141 (21%) did not receive PI (control); 530 (79%) received PI (PI). This cohort of EP infants was born at outside hospitals and transferred to our level IV NICU with a mean age on admission of 13 days, well after the PI would have been administered.RESULTS:
No difference existed between the control and PI groups in gestational age, birth weight, severity of illness, other in-hospital outcomes or developmental delay. PI infants had a significantly lower mortality rate (P=0.0004), lower relative risk (RR) for mortality 0.52 (95% confidence interval (CI) 0.37 to 0.73, P=0.0001) and lower RR of developing the combined outcome of death or bronchopulmonary dysplasia (RR 0.91, 95% CI 0.85 to 0.98, P=0.012) when compared with the control group. Notably, there was no significant effect of PI on incidence of severe intraventricular hemorrhage or patent ductus arteriosus ligation.CONCLUSION:
PI administration was associated with improved survival in EP infants referred to a level IV Children's Hospital NICU.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de salud:
1_doencas_nao_transmissiveis
/
2_muertes_prevenibles
/
6_cardiovascular_diseases
/
6_cerebrovascular_disease
/
6_congenital_chromosomal_anomalies
/
6_other_circulatory_diseases
/
6_other_respiratory_diseases
/
7_neonatal_care_health
/
7_non_communicable_diseases
Asunto principal:
Displasia Broncopulmonar
/
Indometacina
/
Quimioprevención
/
Conducto Arterioso Permeable
/
Hemorragia Cerebral Intraventricular
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
Límite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Perinatol
Asunto de la revista:
PERINATOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos